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Marijuana in its herbal form and hashish in its resinous form is a psychoactive product of the plant Cannabis sativa. The herbal form of the drug consists of dried mature inflorescences and subtending leaves of pistillate ("female") plants. The resinous form consists primarily of glandular trichomes collected from the same plant material. The major biologically active chemical compound in cannabis is tetrahydrocannabinol, commonly referred to as THC. It has psychoactive and physiological effects when consumed, usually by smoking or ingestion. The minimum amount of THC required to have a perceptible psychoactive experience is 5 mg. Humans have been consuming cannabis since prehistory, although in the 20th century there was a rise in its use for recreational, religious or spiritual, and medicinal purposes. It is estimated that cannabis is now regularly used by four percent of the world's adult population, with estimates of up to 20% or greater of the adult population in the United States having tried the drug, and 10–30% or greater using the herb in many European countries. The possession, use, or sale of psychoactive cannabis products became illegal in most parts of the world in the early 20th century. Since then, some countries have intensified the enforcement of cannabis prohibition while others have reduced the priority of enforcement, almost to the point of legalization, as is the case in the Netherlands. The production of cannabis for drug use remains illegal throughout most of the world through the 1961 Single Convention on Narcotic Drugs, the 1971 Convention on Psychotropic Substances, and the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, while simple possession of small quantities is either legal, or treated as an addiction rather than a criminal offense in a few countries. The laws in the United States vary from state to state, some having decriminalized the possession of small amounts of marijuana although it is still a federal crime. Botanists have determined that Cannabis is native to central Asia, possibly extending southward into the Himalayas. Evidence of the inhalation of cannabis smoke can be found as far back as the Neolithic age, as indicated by charred Cannabis seeds found in a ritual brazier at an ancient burial site in present day Romania The most famous users of cannabis were the ancient Hindus of India and Nepal, and the Hashshashins (hashish eaters) of present day Syria. The herb was called ganjika in Sanskrit (ganja in modern Indian and Nepali languages). The ancient drug soma, mentioned in the Vedas as a sacred intoxicating hallucinogen, was sometimes associated with cannabis. Cannabis was also known to the Assyrians, who discovered its psychoactive properties through the Aryans. Using it in some religious ceremonies, they called it qunubu or the drug for sadness. Cannabis was also introduced by the Aryans to the Scythians and Thracians/Dacians, whose shamans (the kapnobatai - "those who walk on smoke/clouds") burned cannabis flowers to induce a state of trance. Members of the cult of Dionysus, believed to have originated in Thrace, are also thought to have inhaled cannabis smoke. In 2003, a leather basket filled with Cannabis leaf fragments and seeds was found next to a 2,500 to 2,800 year old mummified shaman in the northwestern Xinjiang Uygur Autonomous Region of China. Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices by the Scythians occurred during the 5th to 2nd century BCE, confirming previous historical reports by Herodotus. Some historians and etymologists have claimed that cannabis was used as a religious sacrament by ancient Jews, early Christians and Muslims of the Sufi order. In India and Nepal, it has been used by some of the wandering spiritual sadhus for centuries, and in modern times the Rastafari movement has embraced it as a sacrament. Elders of the modern religious movement known as the Ethiopian Zion Coptic Church consider cannabis to be the Eucharist, claiming it as an oral tradition from Ethiopia dating back to the time of Christ. Like the Rastafari, some modern Gnostic Christian sects have asserted that cannabis is the Tree of Life. Other organized religions founded in the past century that treat cannabis as a sacrament are the THC Ministry,the Way of Infinite Harmony, Cantheism, the Cannabis Assembly and the Church of cognizance. Many individuals also consider their use of cannabis to be spiritual regardless of organized religion. When the ancient Hindus or Vedic "Dharmas" used this drug they would often pray for increased wisdom. The American Marijuana Policy Project states that cannabis is an ideal therapeutic drug for cancer and AIDS patients, who often suffer from clinical depression, and from nausea and resulting weight loss due to chemotherapy and other aggressive treatments. It is claimed that cannabis makes these other treatments more tolerable. The nausea suppression and mild analgesic effects of cannabis also provide a degree of relief for persons suffering from motion sickness, and it can also be used by hyperhidrosis sufferers for temporary relief of excessive sweating. A recent study by scientists in Italy has also shown that cannabidiol (CBD), a chemical found in marijuana, seriously inhibits the growth of cancer cells (including breast cancer) in animals. The "Munchies" is a term that is often used to describe the increased appetite that comes from using Cannabis. Research performed by the National Institutes of Health claimed that marijuana increases food enjoyment and the number of times a person eats each day. Recently, scientists have claimed to be able to explain what causes the increase in appetite, concluding that "endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake." There are a wide variety of methods and apparatus for smoking cannabis. The most popular include the joint, the blunt, the bong, the pipe (more commonly called a "bowl" or "piece"), the shotgun, the chillum, the deffy and the one-hitter or "bat." Cannabis is sometimes smoked within a small enclosed area (such as a car) to trap the smoke, so that it is inhaled with every breath. This is often referred to as "hotboxing," "fishbowling," "baking," "jeaning," "clam-baking," "green-housing", "the aquarium" (in Belgium), creating a "potmosphere," or (in Australia), a "compression session." One can also smoke marijuana in a steam-filled environment (bathroom, sauna), with the added humidity intended to produce a greater high, called a "Jamaican shower". The classic bong is a tube with a small bowl (at the end of a thinner tube) inserted through the side, near the base. The bong is partially filled with water for the smoke to bubble through. The herb is placed in the bowl and ignited. After filling the tube with smoke, it is "cleared" by removing one's finger from a hole in the side called a "choke" (or "carb"), or by pulling the bowl up and out which is called a slide (or a "pull-carb"). Homemade bongs are sometimes made with plastic soda bottles. Smoking marijuana through a bong concentrates the smoke, and it is often followed by fits of coughing and laughter. Variants include the gravity bong (also known as a bucket bong), which consists of a cone atop a perforated or cut water bottle. This method of cannabis smoking is one of the most efficient, as the presence of a chamber and "carburetor" hole reduce smoke waste. With a bong, one can consume greater amounts of cannabis in one "hit" than with an ordinary pipe. Another similar smoking device is known as a "waterfall bong". This is usually made by poking a hole in the bottom of a plastic water bottle and either sticking a bowl through a hole in the cap, or resting the bowl over the top. The hole in the bottom is covered with a finger, and the bottle filled with water. The bowl is placed on top of the bottle and lit by holding a flame over it and moving the finger covering the hole. As the water drains out, a vacuum is created, pulling smoke into the bottle. When the water has all drained out, the bowl is removed and the smoke is sucked out of the bottle, often very quickly. The effects of this type of bong are usually felt almost immediately, and often very intensely. Pipes are usually made of blown glass, wood, or non-reactive metals. Metal pipes are often made of interchangeable pieces. Glass pipes often have a "carburetor" hole, colloquially referred to as a carb, rush, choke, shotgun, or shooter Pipes are usually made of blown glass, wood, or non-reactive metals. Metal pipes are often made of interchangeable pieces. Glass pipes often have a "carburetor" hole, colloquially referred to as a carb, rush, choke, shotgun, or shooter (British use) that is covered for suction and then released to draw a mixture of smoke and air into the lungs. Some users prefer vertically held pipes (chillums), or improvised pipes (e.g., "tinnies" or "foilies") made from aluminium foil, small plumbing fittings, soda cans, crisp fruits or vegetables, or the cardboard tubes from bathroom-tissue or aluminium foil rolls. A "one-hitter" is a device that enables a small amount of cannabis to be burned and inhaled in a single breath. The cannabis is loaded into one end of a small screenless tube (usually brass), and the entire amount is smoked at once. This is repeated for each hit. This method is useful for carefully titrating the desired dose. One-hitters are often disguised to fool people into believing that one is smoking an authentic cigarette. This deception is more effective (but less healthy) if the cannabis is mixed with a little tobacco. The "apple Bowl" is yet another way of smoking cannabis. An apple is poked from the top and side creating a tube.Marijuana is then placed in the top opening and lit.The user then inhales the smoke from the other opening. Effects of smoking marijuana: Some physical effects are dry mouth, dry eyes, increased heart rate, bloodshot eyes, and puffy eyelids. The psychological effects are relaxation, euphoria, altered time perception, and alteration of visual, auditory, and olfactory senses. There are also some negative effects of marijuana use but there seem to be no real chronic effects. Short-term effects of marijuana use are; short-term memory loss, anxiety, irritation, . Once the person quits smoking or ingesting THC, the side effects soon disappear. As an alternative to smoking, cannabis may be consumed orally. Although hashish is sometimes eaten raw or mixed with water, THC and other cannabinoids are more efficiently absorbed into the bloodstream when dissolved in ethanol, or combined with butter or other lipids. The effects of cannabis administered this way take longer to begin, but last longer. They are sometimes perceived as more physical than mental, although there are many claims to the contrary. An oral dose of cannabis is often considered to give a more intense experience than the equivalent dose of smoked cannabis. Some people report unpleasant experiences after ingesting cannabis, because they experience a more intense effect than they are comfortable with.