Nktar profile picture

Nktar

"NK-triggering-antigen regulator" 202-0 off me uh

About Me

(Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny for (1) relative level of competitive inhibition of BALB/c NK lysis of syngeneic Con A blasts and (2) genotypes at polymorphic microsatellite markers distributed throughout the mouse genome mapped the Nktar gene locus to a 5-cM region of chromosome 10 containing the interferon-gamma receptor (Ifngr) gene locus. N2 Con A blasts exhibited an inverse relationship between (a) their cell surface density of IFN-gammaR molecules detected by FACS with monoclonal anti-CD119 and (b) their cold target inhibition of BALB/c NK self-reactivity. Con A blasts from Ifngr(-/-) knockout mice showed a relatively high level of inhibition of BALB/c NK self-lysis and a relatively low level of class I MHC, which were both reversed by transient transfection with the Ifngr gene. Sequencing studies showed that Balb/c Ifngr encodes a Gly(69) whereas C57BL/6 Ifngr encodes Glu(69) due to a difference at nucleotide 284. Sequencing studies of N2 progeny demonstrated 100% concordance between their Nktar inhibitory phenotype and their Ifngr genotype. These findings demonstrate that the Nktar and Ifngr loci are identical. They further indicate that polymorphisms related to the Ifngr locus and affecting expression of cell surface IFN-gammaR may underlie genetic differences in the availability of NK-triggering antigens (NKTAgs) to recognition by self-reactive BALB/c NK cells by differentially affecting the ability of IFN-gammaR molecules to mediate up-regulation of NKTAg-masking class I molecules.Layout Created at Chasebadkids.net

My Interests

Music:

Member Since: 11/1/2005
Band Website: outsidrecordings.com
Band Members: Tropa and Spytek
Influences: unexpectedly as total Darkness-‹berhit entpuppt, that with delayten Claps very effective and only two sounds a quiet exclaims on the Dancefloor, that seeks people like her.With deeply wobbelnder Bassline it pulls one middle purely in this Oldschool-swirl.Hammer, hammer, deeper hammer.There for: Interferon-gamma receptor polymorphisms determine strain differences in accessibility of activated lymphocyte NK-triggering antigens to recognition by self-reactive NK cells NK cells NK cells NK cells NK cells NK cells NK cells NK cellsv NK cells.
Sounds Like: The Beats on the other hand seem mix frontal out of that to come, control is content itself the direct Impact, that is responsible for the brutal, Dumdum-Geschossartige in Electro, that not therewith, tear wants the Hˆrprozess to penetrieren, but rather as deep as possible holes.
Record Label: outside recordings
Type of Label: Indie

My Blog

nktars world domination

dom·i·na·tion Pronunciation: "dä-m&-'nA-sh&n Function: noun 1 : supremacy or preeminence over another 2 : exercise of mastery or ruling power 3 : exercise of preponderant, governing, or controll...
Posted by Nktar on Thu, 15 Dec 2005 06:51:00 PST