Jan Solo

According to the Merck Index, 12th edition, the LD50, the lethal dose for 50% of rats tested by inhalation, is 42 mg/kg of body weight. That is the equivalent of a 165 lb (75 kg) man inhaling all of the THC in 21 one-gram cigarettes of high-potency (15% THC) cannabis buds at once, assuming no THC was lost through burning or exhalation, though a substantial amount of THC is lost through smoking, making the actual amount of cannabis required higher. For oral consumption, the LD50 of THC for rats is 1270 mg/kg and 730 mg/kg for males and females, respectively, equivalent to the THC in about a pound of 15% THC cannabis. Only with intravenous administration may such a level be even theoretically possible.[29] The ratio of cannabis required to saturate cannaboid receptors to the amount of cannabis required to have a fatal over dose is 1:40,000. All this means, my habit is by far the least deadly of all.