A native of Riverside, California, Kellie Martin loved to perform for her close-knit family. She began her acting career at age seven, when her aunt Rhonda Jett (mother of Kyle Jett), a nanny for actor Michael Landon's children, helped Martin land a guest spot on the Landon produced series Father Murphy.
Among many roles in motion pictures, made-for-TV movies and television series, she is perhaps most famous for her role as Rebecca "Becca" Thatcher on the drama Life Goes On, which ran on ABC (1989–1993), and for her role as med student Lucy Knight on the NBC drama ER (1998–2000). Martin also contributed the voice of Daphne Blake on the animated series A Pup Named Scooby-Doo.
Martin graduated from Yale University in 2001 with a degree in art history. She was a member of Saybrook College.
She married Keith Christian in May 15, 1999 in his hometown of Polson, Montana. The pair had their first child, a daughter named Margaret Heather Christian, on November 4, 2006. She is named after Martin's sister Heather, who died due to lupus erythematosus at age 19.