My Des·ti·ny [des-tuh-nee] 1. something that is to happen or has happened to a particular person or thing; lot or fortune. 2. the predetermined, usually inevitable or irresistible, course of events. 3. the power or agency that determines the course of events. 4. (initial capital letter) this power personified or represented as a goddess. 5. the Destinies, the Fates.