Alyssa Milano (Phoebe Halliwell )Best known for her role on the long-running comedy Who's the Boss? Alyssa Milano literally grew up on television. Born and raised in Brooklyn, N.Y., Milano got her start with the national touring company of Annie. At 10, she was cast as Samantha Micelli in Who's the Boss? and starred opposite Tony Danza for eight years. More recently, Milano starred for two seasons on Melrose Place and in Gold Rush, an original television movie on The Wonderful World of Disney.Feature film credits include the title role in the feature comedy Hugo Pool, the psychological thriller Fear, Double Dragon, Where the Day Takes You, Commando, Little Sister and Below Utopia. She has starred in a wide range of television movies including Braving Alaska, The Surrogate, Conflict of Interest, and Candles in the Dark. She also guest-starred in an episode of Showtime's Rebel Highway.On stage, Alyssa starred in Tender Offer, All Night Long, the first American musical adaptation of Jane Eyre and Butterflies Are Free, which she also produced.Rose McGowan (Paige Matthews)Rose McGowan, who catapulted to big-screen stardom with edgy roles in films such as The Doom Generation and Scream, joins the cast of Charmed as Paige Matthews, a long-lost sister of the Charmed Ones.One of six children in her family, McGowan was a citizen of the world at an early age. Raised in Italy, she spent her childhood traveling throughout Europe. She returned to the U.S. in order to attend high school and moved to Seattle. A chance trip to Los Angeles resulted in her being cast in the film The Doom Generation. Her performance in Gregg Araki's dark and stylish road movie earned her a nomination for Best Newcomer at the 1996 Independent Spirit Awards. Also in 1996, Rose appeared in Wes Craven's smash hit Scream as Sydney's (Neve Campbell) doomed best friend who met with an unseemly death under a garage door.Since this auspicious debut, McGowan has worked non-stop. In 1997, she had starred in four films appearing at the Sundance Film Festival: Going All the Way, Louis & Clark & George, Nowhere and the short film Seed. In 1998, Rose starred with Ben Affleck and Peter O'Toole in the feature thriller Phantoms and in the independent film Southie, which won Best Picture at the 2000 Seattle Film Festival. Recent roles include the 2006 mystery The Black Dahlia and multiple roles in Quentin Tarantino's Grindhouse. Holly Marie Combs (Piper Halliwell )Holly Marie Combs, popular with audiences for her role as teen-aged Kimberly Brock on the Emmy Award-winning series Picket Fences, returned to series television in Charmed. On the big screen, she is seen in Steven Soderbergh's remake of Ocean's Eleven, opposite George Clooney and Brad Pitt, in which she plays herself, along with Barry Watson and Joshua Jackson.Combs was born in San Diego, Calif., and moved with her family to New York when she was eight years old. Following in her mother's footsteps as an aspiring actress, she began her career working in television commercials and print advertisements at age 10. She won her first movie role by 13, playing the daughter of Don Johnson and Susan Sarandon in the feature film Sweet Hearts Dance.At 18, Combs got her big break starring for four seasons in the critically acclaimed drama Picket Fences In television movies, she has played an impressive range of starring roles, including the daughter of a murdered heiress in the fact-based Daughters, killer Diane Zamora in Love's Deadly Triangle: The Texas Cadet Murder and a rape victim in Sins of Silence. Feature film work includes Born on the Fourth of July, Chain of Desire and Simple Men.