Michael Scofield - Wentworth Miller
Lincoln Burrows - Dominic Purcell
Fernando Sucre – Amoury Nolasco
Theodore Bagwell – Robert Knepper
Benjamin Miles Franklin – Rockmond Dunbar
Charles Patoshik – Silas Weir Mitchell
John Abruzzi – Peter Stormare
David Apolskis – Lane Garrison
Sarah Tancredi – Sarah Wayne Callies
Paul Kellerman – Paul Adelstein
Veronica Donovan – Robin Tunney
Nick Savrinn – Frank Grillo
Brad Bellick – Wade Williams
Alexander Mahone – William Fichtner
Caroline Reynolds – Patricia Wettig
Lincoln Junior – Marshall Allman
William Kim – Reggie Lee Joliet