Harris is an FBI agent long specializing in investigation of the DiMeo/Soprano crime family. While investigating the family, he develops a somewhat friendly rapport with several of its members, particularly Tony Soprano. Recently returned to the United States after being assigned to counter-terrorism duty in Pakistan, where he caught a bad stomach parasite. Nevertheless, he frequents Satriale's pork store, apparently for the familiar food and company, but has also approached Christopher for information on terrorism-related organized crime. With Harris now focused on terrorism, he and Tony seem to develop a more genuine friendship. In the Season 6 episode "Kaisha", Harris appears at Satriale's to inform Tony that someone in his crew could be in danger, although he had no specific details.Later on, Agent Harris and his partner, Agent Goddard, approached Tony at his home, requesting that Tony inform them should he come across any terror-related information in his line of work. Tony initially rejects the overture, but has a change of heart after suspecting that two Muslim former patrons of the Bada Bing, who had been paying Christopher Moltisanti for stolen credit card numbers, were involved in terrorist activity. Tony provides their names and a cell phone numbers to Agent Harris, who is appreciative. In return, Agent Harris promises to write a letter detailing Tony's assistance that will be placed in Tony's FBI file for a judge to consider in sentencing should Tony ever be convicted of a crime. Harris and Soprano seemed to have established a mutual respect at this point; Tony views anti-terrorism as an important issue and Harris appreciates that Tony's leadership is preferable to that of mobsters like Leotardo. He later tells Tony at Satriale's that an informer amongst Phil Leotardo's crew has told them that Tony is being targeted by the Lupertazzi family. Agent Harris meets with Tony Soprano, who offers him the name of the Muslim men's bank. In return, Harris tells Tony that Leotardo has been making calls from a pay phone in Oyster Bay, Long Island, information he apparently obtains from an agent with whom he is having an affair. When Agent Goddard later reports Leotardo's murder, Harris exults in the success of his ploy.
"How do we cripple national and international organized crime syndicates that strangle free enterprise and raise the level of violence, fraud, and corruption in our cities? By using every capability and tool we’ve got: undercover operations; surveillance; confidential sources; intelligence analysis and sharing; forensic accounting; multi-agency investigations; and the power of racketeering statutes that help us take down entire enterprises. We also work closely with our international partners—in some cases, swapping personnel—to build cases and disrupt syndicates with global ties."