Albert Hoffman

For eight years, chemist Prof. Albert Hofmann had been methodically synthesising new molecules from ergot, a fungus which grows on diseased rye.Ergot had an intriguing contradictory reputation. On the one hand, it was highly-regarded in folk medicine for speeding up the contractions during childbirth. On the other, it was the cause of St Anthony's Fire, an horrific scourge that had blighted entire Medieval villages with gangrene, madness and death when it infected their grain stores. Hofmann chose April 16th, 1943 to re-investigate LSD-25, a molecule he had synthesised five years earlier.It took all morning to crystallise a batch of the fine white powder but, by midday, he found himself feeling strangely restless and dizzy. Thinking he was coming down with a cold, he took the afternoon off and went to bed.Then the hallucinations began."An uninterrupted stream of fantastic images of extraordinary plasticity and vividness," passed before his eyes, "accompanied by an intense kaleidoscopic play of colours."After two hours, the effects abated and Hofmann was left breathless and wondering. What the hell?Suspecting that LSD-25 was at the root of the weirdness, he returned to his lab on Monday to investigate. He dissolved what he thought was a prudent amount - 250 millionths of a gram - in water and drank it down. It was actually a massive dose.40 minutes later he became dizzy, observed some visual disturbance and had a strong desire to laugh. He asked his assistant to call a doctor and then proceeded to cycle home.It was the strangest cycle-ride of his life. The buildings around him "yawned and rippled" and although he pedalled steadily, he didn't appear to be moving. Eventually he got home, but by now believed he had permanently lost his mind. When a friendly neighbour brought round some milk, he perceived her as a "malevolent, insidious witch" wearing "a lurid mask."After six hours of highs and lows, the effects subsided and Hofmann finally fell asleep.He awoke the next day knowing he had discovered a new and extremely powerful conscious-altering substance. He didn't know however, the effect his "problem child" would have on his career, an entire generation, and the world.I edited my profile with Thomas' Myspace Editor V4.4